...And now Steve is popping my easy bubble and telling me not to use the Mobile First template...
It really depends on the purpose of your design. If the site is actually primarily for mobile and you're just including desktop as a courtesy, then Mobile First makes sense.
For me it's kind of like working with a jpg image. If someone gives you a full-size 300dpi image, you can always reduce it and not lose much quality. If they give you a small one and you need it large, you can't enlarge it without some serious pixelization. It's much easier for me to start with the large design and remove or change elements as the screen becomes smaller than to expand them going the other direction.
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