Let me say from the onset that it was well worth the effort to make a section of our very large website responsive using RSD. The learning curve is steep, stepping from FrontPage to RSD.
This answer is not specific to your question, but it might be of help in getting a sound baseline for a very large website.
RSD has a page limit of 75 pages which requires a work-around. Large number of pages in RSD slows the program down. I opted for the one main RSD project “parent” that has all the templates and main navigation structures. Using save as, I created several “children” RSD projects and deleted all the files, other than the templates, to create space for more files. My reasoning was to have all files under the root directory (short SEO friendly URL)
My main project has all the CSS regulating the website. Careful consideration was given to naming the Type & Class for the styling of the entire website. The “children” projects never have any changes made to Type or Class. I only use ID for that.
It is imperative to save your projects giving descriptive names all the time and keep separate backups. I use Save As to be able to step back if an error creeps in with overwriting CSS.
Page changes and updates to pages can only be done in your RSD projects. A system is needed to find pages easily. Plan this in advance.
With uploads, a sequence of worked projects has to be kept and lastly the main parent project must be uploaded because it has the CSS structure.
Organizing the files within a project is difficult. You have to manually drag a file into some sort of arrangement to help find them later, especially when you've got 75 files per project. I opted for the FrontPage alphabetical system.
This is how I dealt with some of the issues of building a large website in RSD. Other might have a different methodology.
Kind regards,
Anne
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