I'd like to have two seperate shopping carts. One for US shipping and International Shipping becuase they would be uploaded to two different web domains. I think all I have to do is "Save As" to create the second shopping. Next open the new shopping cart and change the shipping rates. Does anyone have two shopping carts set up like this?

Yes, that is correct. The other item you may need to change is the merchant information. Are you going to use different PayPal, Google Checkout or Authorize.net accounts for one of them? If they are the same, then what you described is all you really need to worry about.

Great point! At this time I'll use the same PayPal. I'll keep that in mind if I change accounts.